- She is one of the characters in the game Assassin’s Creed II and Assassin’s Creed Brotherhood, where she has a relationship with the hero of the game, Ezio Auditore.
- She is part of the manga Trinity Blood by Sunao Yoshida.
- She also appears in the Cesare manga by Fuyumi Soryo.
- She appears in the series The Borgias, from 1981: she is played by Diane Fletcher.
- Catherine Sforza played by Gina McKee in the series The Borgias. She is portrayed as a woman of character, taking up arms alongside her family.
- She is present at the end of the second season of the Borgia series, where she attempts to assassinate Alexander VI, then where she shows herself as a woman preferring power to motherly love.
- Catherine Sforza is played by Rose Williams in 2019 in season 3 of the series Les Médicis.
