She was one of the villains sent to abduct Dragon’s children as a way of trying to get the hero to quit the Chicago Police Department. She then attacked Dragon when he was recovering in Hillman Hospital after the initial encounter with the man who would become Virus.
When OverLord III sent an army of Vicious Circle villains to Hillman Hospital to steal the last remaining vial of Dragon’s blood, Bug Lady was present. She was then targeted by Malcolm and Angel Dragon as they sought the location for the missing blood. They ended up defeating the woman and delivering her to the authorities.