Little Miss Muffet

Little Miss Muffet related the adventures of an orphan girl and her fateful dog Hash who are taken in by a country family in Montana, her life however is complicated due to the fact that when she reaches the age of 21 she will inherit a large tract of land and a school, there are to be sure some wicked people willing to do anything to get get their hands on both items.
 
Created by Fanny Y. Cory in 1935, this King Syndicate strip ran in the papers until 1956.  
 
She was based not on the tuffet setting Muffet but more on a mix of Little Orphan Annie and Shirley Temple.